MexDrugs
MexDrugs is a database of genetic interactions that are predicted to be mutually exclusive in the cancer tissue of choice by the algorithm MexD. MexD uses matched somatic mutation, copy number variance and methylation data from The Cancer Genome Atlas, together with drug information from the Druggable genome databank, to predict cancer-associated genes that may be synthetically lethal with genes that are inhibited by existing drugs.
Breast cancer Within breast cancer there are 512 drugs that inhibit genes predicted to be mutually exclusive. These are listed in the drop-down box below, and link to the pages giving MexDrugs predictions.
MexDrugs (7S)-HYDROXYL-STAUROSPORINE (R,S)-4-PPG (S)-3,4-DCPG 23814 5-(N,N-HEXAMETHYLENE)-AMILORIDE 6-DIAZO-5-OXO-L-NORLEUCINE 7-HYDROXYSTAUROSPORINE 9-CIS-RETINOIC ACID [125I][DES-GLY10,D-ALA6]GNRH N-ETHYLAMIDE [125I][NLE8,21,TYR34]PTH-(1-34)-NH2 (RAT) [125I][TYR5,DALA6,NMELEU7,PRO9-NET]GNRH [125I]CETRORELIX [125I]GNRH I (HUMAN, MOUSE, RAT) [3H]NBI-49202 [AC-D-2NAL1,D4CPA2,D-3PAL3,6,LEU8, D-ALA10]GNRH-II [D-LYS6]GNRH-II [D-TRP12,TYR34]PTH-(7-34) (BOVINE) [D-TRP12]PTH-(7-34) (BOVINE) [GLN8]GNRH [HIS5,D-TYR6]GNRH [HIS5]PTH-(1-34) (HUMAN) [ILE5,TRP23,TYR36]PTHRP-(1-36)-NH2 (HUMAN) [ILE5,TRP23]PTHRP-(1-36) (HUMAN) [ILE5,TRP23]PTHRP-(2-36) (HUMAN) [ILE5,TRP23]PTHRP-(3-36) (HUMAN) [ILE5,TRP23]PTHRP-(4-36) (HUMAN) [ILE5,TRP23]PTHRP-(5-36) [ILE5,TRP23]PTHRP-(5-36) (HUMAN) [ILE5]PTHRP-(1-36) [PHE23]PTH-(1-34) (HUMAN) [SER8]GNRH [TRP23,TYR36]PTHRP-(1-36)-NH2 (HUMAN) [TRP23]PTHRP-(1-36) (HUMAN) [TRP8]GNRH [TYR8]GNRH ABARELIX ABEMACICLIB ABP 980 ABT-414 AC-480 AC480 ACALABRUTINIB ADCT-502 ADJUVANT ADO-TRASTUZUMAB EMTANSINE ADX88178 ADXS31-164 AE37 AEE 788 AEE-788 AEE788 AFATINIB AFATINIB DIMALEATE AFFINITAC AG 879 AKTI-1/2 ALARELIN ALL-TRANS-RETINOIC ACID ALLITINIB ALPHA-TOCOPHEROL ALVESPIMYCIN ALVESPIMYCIN HYDROCHLORIDE ALX1-11 AMG 337 AMG102 AMITRIPTYLINE HYDROCHLORIDE AMOXAPINE ANALOGUES ANASTROZOLE ANTAGONIST ANTARELIX ANTHRAQUINONE ANTI-CANCER AGENTS ANTIANGIOGENIC AP32788 AR-42 ARA-C ARI-3037MO ARQ092 ARRY-334543 ARRY-380 ARRY380 ARSENIC TRIOXIDE AT13148 AT13387 AUTOLOGOUS DENDRITIC CELLS AUY922 AV-412 AVAGACESTAT AZ4800 AZD4547 AZD8055 AZD8931 AZD9291 BALANOL BAY1000394 BC11-38 BCG BEGACESTAT BELINOSTAT BEVACIZUMAB BEVACIZUMAB+TRASTUZUMAB BGB-283 BIBW 2992 BIIB021 BKM120 BMS-299897 BMS-599626 BMS-690514 BMS-708163 BRAIN-DERIVED NEUROTROPHIC FACTOR BRL50481 BRYOSTATIN BRYOSTATIN-1 BUSERELIN CAFFEINE CANERTINIB CANERTINIB DIHYDROCHLORIDE CAPECITABINE CB-839 CDX-3379 CEP-2563 CETRORELIX CETRORELIX ACETATE CETUXIMAB CH5132799 CHEMOTHERAPY CHF-5074 CHLORAMBUCIL CHLORPHENTERMINE HYDROCHLORIDE CI-1033 CI-1040 CISPLATIN CITALOPRAM HYDROBROMIDE CLOFARABINE CLOMIPRAMINE HYDROCHLORIDE CMPD-1 CNF1010 CO1686 COLCHICINE COMPOUND 1 [PMID: 16650987] COMPOUND 1 [PMID: 21882820] COMPOUND 1 [PMID: 22465637] COMPOUND 11 [PMID: 16413183] COMPOUND 11 [PMID: 20638279] COMPOUND 17 [PMID: 23642479] COMPOUND 22A [PMID: 21688779] COMPOUND 25 [PMID: 17935989] COMPOUND 38 [PMID: 24915291] COMPOUND 7 [PMID: 20638279] COPANLISIB CP-724714 CRISABOROLE CRIZOTINIB CT-P6 CUDC-101 CUDC-907 CYCLOPHOSPHAMIDE CYCLORELIX CYCLOSPORIN A D-23487 D-24710 DACOMITINIB DACOMITINIB HYDRATE DALFAMPRIDINE DANAZOL DASOTRALINE DEBIO 0932 DEGARELIX DEGARELIX ACETATE DEPSIPEPTIDE DES DESLORELIN DESVENLAFAXINE DESVENLAFAXINE FUMARATE DESVENLAFAXINE SUCCINATE DEXAMETHASONE DEXTRAN SULFATE SODIUM DIPYRIDAMOLE DOCETAXEL DOXORUBICIN DS-8201A DULOXETINE HYDROCHLORIDE DYPHYLLINE E2012 E75 EGFR/ERBB-2 INHIBITOR EGFR/ERBB-2/ERBB-4 INHIBITOR EKI-285 ELAGOLIX ELND006 EMODIN ENTINOSTAT ENU ENZASTAURIN EP-100 EP-2101 EPIRUBICIN ERLOTINIB ERTUMAXOMAB ESCITALOPRAM OXALATE ESI-09 ETHANOL EVEROLIMUS EXEMESTANE FALNIDAMOL FAXELADOL FD-1 FERTIRELIN FF-284 FILGRASTIM FLAVOXATE HYDROCHLORIDE FLUDARABINE FLUDARABINE PHOSPHATE FLUORODEOXYURIDINE FLUOROURACIL FLUOXETINE HYDROCHLORIDE FLUVOXAMINE MALEATE FP0429 FR901228 FULVESTRANT GALLIUM NITRATE GANCICLOVIR GANETESPIB GANIRELIX GANIRELIX ACETATE GDC-0032 GDC-0941 GEFITINIB GEMCITABINE GEMCITABINE HYDROCHLORIDE GGF-2 GLUCOCORTICOID GLUTAMINE GNRH I GNRH II GNRH III GONADORELIN GONADORELIN ACETATE GONADORELIN HYDROCHLORIDE GOSERELIN GOSERELIN ACETATE GREEN TEA POLYPHENOLS GSI-136 GSK-690693 GSK163090 GUANIDINE HYDROCHLORIDE GW2016 GÖ 6976 GÖ 6983 H-PTH 1-34 HEMAY-022 HER2 CAR-T CELLS HER2 VACCINE HER2-PULSED DC1 VACCINE HERCEPTIN HERTUZUMAB-VC-MMAE HERZYME HISTERELIN HISTRELIN HISTRELIN ACETATE HJC 0350 HKI-272 HSP90 HSP90 INHIBITOR HYDROCORTISONE HYDROGEN PEROXIDE HYDROXYUREA IAP ANTAGONIST IBRUTINIB IL-12 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE PAMOATE IN-3 INGENOL MEBUTATE INHIBITOR INSM-18 INSULIN IONOMYCIN IPATASERTIB IPI-504 IRBINITINIB IRESSA IRINOTECAN ISIS 113715 ISIS-PTP1B ISOFLAVONES ITI-007 ITURELIX JNJ-26483327 KLH-2109 KRIBB11 KU004 L-AP4 L-GLUTAMIC ACID L-SERINE-O-PHOSPHATE LAPATINIB LAPATINIB DITOSYLATE LAPULEUCEL-T LEE011 LETROZOLE LEUCOVORIN LEUPROLIDE LEUPROLIDE ACETATE LEUPRORELIN ACETATE LEVAMISOLE LEVOMILNACIPRAN HYDROCHLORIDE LHRH LIAFENSINE LJM716 LOMITAPIDE MESYLATE LOR-2040 LSP4-2022 LU AF21934 LUTEINIZING HORMONE-RELEASING HORMONE LY2835219 LY341495 LY411575 MAPK INHIBITORS MARGETUXIMAB MAZINDOL MDX-210 METFORMIN METHAMPHETAMINE HYDROCHLORIDE METHOTREXATE MFOLFOX6 MGAH22 MGCD-0103 MIDOSTAURIN MILNACIPRAN HYDROCHLORIDE MK0752 MK2206 ML315 MM-111 MM-302 MM111 MOTEXAFIN GADOLINIUM MP-412 MPC-3100 MPEP MUBRITINIB MVA-BN-HER-2 MYL-1401O NAFARELIN NAFARELIN ACETATE NAX014 NBI-42902 NBI-56418 NEFAZODONE HYDROCHLORIDE NERATINIB NERISPIRDINE NIFEDIPINE NITROGEN MUSTARD NORTRIPTYLINE HYDROCHLORIDE NSAID OLAPARIB ONARTUZUMAB OR OSIMERTINIB OSIMERTINIB MESYLATE OSTABOLIN-C OXALIPLATIN OZARELIX PACLITAXEL PALBOCICLIB PANITUMUMAB PANOBINOSTAT PANOBINOSTAT LACTATE PARATHYROID HORMONE PAROXETINE HYDROCHLORIDE PAROXETINE MESYLATE PAZOPANIB + TYVERB/TYKERB PD 0332991 PD-98059 PELITINIB PENTOXIFYLLINE PERTUZUMAB PF-05212384 PF-05280014 PF03084014 PHCCC PICTILISIB PKI-179 PLATINUM PMA POLYPHENOL PONATINIB POZIOTINIB PRACINOSTAT PROTEASE INHIBITORS PROTRIPTYLINE HYDROCHLORIDE PTH 1-34 PTH-(1-34) (RAT) PTHRP-(1-21)/PTH-(22-34) (HUMAN) PTHRP-(1-34) (HUMAN) PTHRP-(1-36) PTHRP-(7-34) (HUMAN, RAT, MOUSE) PX 104.1 PXT002331 PYROTINIB QUISINOSTAT R115777 RADIOTHERAPY RAMUCIRUMAB RAPAMYCIN (SIROLIMUS) RELUGOLIX RESMINOSTAT RETASPIMYCIN RETASPIMYCIN HYDROCHLORIDE RETINOIC ACID RO 4929097 RO4929097 ROCILETINIB ROMIDEPSIN RUBOXISTAURIN S-222611 S63845 SAPITINIB SB3 SB939 SCH-900229 SELUMETINIB SEMAGACESTAT SERIBANTUMAB SERTRALINE HYDROCHLORIDE SIB-1893 SIBUTRAMINE HYDROCHLORIDE SNX-5422 SNX0723 SOPHORETIN SORAFENIB SOTRASTAURIN SOTRASTAURIN ACETATE STA-9090 STAUROSPORINE SUBEROYLANILIDE HYDROXAMIC ACID SUFUGOLIX SUNITINIB SYD985 T-98475 T-DM1 TACEDINALINE TADALAFIL TAK-285 TAK-385 TAK165 TAMOXIFEN TANESPIMYCIN TARENFLURBIL TEDATIOXETINE TEDISAMIL TEMSIROLIMUS TENSIROLIMUS TERIPARATIDE TESEVATINIB TEZACITABINE TILUDRONATE TIP39 TIP39-(7-39) (HUMAN/BOVINE) TIP39-(7-39) (MOUSE) TIVOZANIB TORKINIB TRASTUZUMAB TRASTUZUMAB EMTANSINE TRASTUZUMAB-DM1 TRAZODONE HYDROCHLORIDE TRETINOIN TRIAPINE TRIFLUOPERAZINE TRIPTORELIN TRIPTORELIN PAMOATE TRODUSQUEMINE TROGLITAZONE TS-1 TUCATINIB TYKERB TYRPHOSTIN AG 879 TYVERB/TYKERB URACIL VACCINE ADJUVANT VALPROIC ACID VANDETANIB VARLITINIB VASOPRESSIN VENLAFAXINE HYDROCHLORIDE VILAZODONE HYDROCHLORIDE VINORELBINE VIROSOME-BASED BREAST CANCER VACCINE VISTUSERTIB VITAMIN B3 VITAMIN E VORINOSTAT VORTIOXETINE HYDROBROMIDE VS-5584 VU0001171 VU0080241 VU0092145 VU0155041 VU0359516 VU0361737 VU0364770 VU0400195 WAY-207024 WITHACNISTIN WZ4002 XL147 XL147 (PILARALISIB) XL647 XL888 XMT-1522 ZOPTARELIN DOXORUBICIN ZW25
