MexDrugs
MexDrugs is a database of genetic interactions that are predicted to be mutually exclusive in the cancer tissue of choice by the algorithm MexD. MexD uses matched somatic mutation, copy number variance and methylation data from The Cancer Genome Atlas, together with drug information from the Druggable genome databank, to predict cancer-associated genes that may be synthetically lethal with genes that are inhibited by existing drugs.
Large_intestine cancer Within large_intestine cancer there are 332 drugs that inhibit genes predicted to be mutually exclusive. These are listed in the drop-down box below, and link to the pages giving MexDrugs predictions.
MexDrugs (+)-ACECLIDINE (-)-ACECLIDINE (7S)-HYDROXYL-STAUROSPORINE 4-DAMP 5-FLUORODEOXYURIDINE 6-HYDROXYDOPAMINE 6-OHDA [125I]CCL1 (HUMAN) [125I]CNP (HUMAN) [3H]D-ASPARTIC ACID [3H]L-ASPARTIC ACID [3H]N-METHYL SCOPOLAMINE [3H]QNB [SER11](N-CNP,C-ANP)PBNP2-15 ABCIXIMAB ACALABRUTINIB ACETYLCHOLINE ACLIDINIUM ACTINOMYCIN D AE9C90CB AFACIFENACIN AFDX384 ALCURONIUM ALDESLEUKIN AMITRIPTYLINE ANTI-EGFL7 ANTI-INFLAMMATORY DRUGS ANTIANGIOGENIC ANTITHROMBIN APITOLISIB AQ-RA 741 AR-H067637 ARECAIDINE PROPARGYL ESTER ARECOLINE ARGATROBAN ARRY-403 ASPIRIN ATORVASTATIN ATRA ATROPINE AZ12971554 AZD-0837 AZD-6482 AZD0837 AZD1656 AZD5658 AZD6370 BALANOL BASILIXIMAB BAY80-6946 BENZQUINAMIDE BETHANECHOL BEZ235 BGJ398 BGT-226 BIPERIDEN BIVALIRUDIN BKM120 BORTEZOMIB BOSUTINIB BPKDI BRENTUXIMAB VEDOTIN BRUCINE BRUCINE N-OXIDE BRYOSTATIN BRYOSTATIN-1 BUPARLISIB BUPARLISIB HYDROCHLORIDE BYL719 C-TYPE NATRIURETIC PEPTIDE CA2+ CABAZITAXEL CAMPTOTHECIN CARBACHOL CARBENOXOLONE CARBOPLATIN CARDIODILATIN CARFILZOMIB CAROTUXIMAB CCL1 CD-NP CENDERITIDE CISPLATIN CLARITHROMYCIN CLOZAPINE COLCHICINE COMPOUND 14 [PMID: 23634668] COMPOUND 20 [PMID:12127536] COMPOUND 23 [PMID: 17600705] COMPOUND 31 [PMID: 23374866] COMPOUND 31 [PMID: 24915291] COMPOUND 38 [PMID: 24915291] COMPOUND 7 [PMID: 22464456] COMPOUND C10 [PMID: 24297249] COPANLISIB CROLIBULIN CRT 0066101 CSA CUDC-907 CYCLOSPORIN A CYTOKINES DABIGATRAN DABIGATRAN ETEXILATE MESYLATE DACLIZUMAB DACTOLISIB DARIFENACIN DAROTROPIUM BROMIDE DAVUNETIDE DENILEUKIN DIFTITOX DERMOLASTIN DES DESIRUDIN DEXAMETHASONE DHEA DIPHENIDOL DIPYRIDAMOLE DL-TBOA DMSO DOCETAXEL DOCETAXEL HYDRATE DOSULEPIN DOXEPIN DOXORUBICIN DS-7423 DUP-714 ENOXAPARIN EP217609 EP42675 EPIRUBICIN EPTIFIBATIDE ERIBULIN MESYLATE ERYTHRITYL TETRANITRATE ERYTHROMYCIN ETHANOL ETHINYL ESTRADIOL ETOPOSIDE FENTANYL FINASTERIDE FLAVOPIRIDOL FLOVAGATRAN FLUFENAMIC ACID FOSBRETABULIN DISODIUM FOSBRETABULIN TROMETHAMINE FURTRETHONIUM GANTOFIBAN GDC-0941 GDC-0980 GEDATOLISIB GEMCITABINE GLUCOCORTICOID GLYCOPYRROLATE GSK-1059615 GSK2126458 GSK2606414 GSK2636771 GÖ 7874 HEPARIN HEXAHYDROSILADIFENIDOL HIMBACINE HOMATROPINE METHYLBROMIDE HORMONES HS142-1 HUMAN INTERLEUKIN-2 HYDROCORTISONE HYDROXYUREA IBRUTINIB IL-2 IL-5 ILOMASTAT INDIBULIN INOLIMOMAB INTERLEUKIN 2 INTERLEUKIN-2 INTERLEUKIN-2 EXPRESSING PLASMID IPRATROPIUM IXABEPILONE IXAZOMIB CITRATE KT 5720 LAMIVUDINE LEPIRUDIN LEUCETTINE L41 LEXIBULIN LIAROZOLE LIDOCAINE LONIDAMINE LY-2599506 LY-3023414 MARIZOMIB MCN-A-343 MEDUSA IL-2 MEGF0444A MELAGATRAN MELATONIN MENADIONE METHOCTRAMINE METHOTRIMEPRAZINE METHYLFURMETHIDE METIXENE MILAMELINE MITOXANTRONE ML381 MORPHINE MPC-0920 MUSCARINIC TOXIN 1 MUSCARINIC TOXIN 2 MUSCARINIC TOXIN 3 MUSCARINIC TOXIN 7 N-BENZYL BRUCINE N-CHLOROMETHYL-BRUCINE NESIRITIDE NITISINONE NNC 11-1314 NNC 11-1585 NNC 11-1607 NSAIDS NU172 OCTANOL OLANZAPINE OMIPALISIB OPROZOMIB OTENZEPAD OXOTREMORINE OXOTREMORINE-M OXYBUTYNIN P-F-HHSID PA-799 PACLITAXEL PACLITAXEL POLIGLUMEX PANULISIB PARSATUZUMAB PENTYLTHIO-TZTP PEPTIDE P19 [PMID: 15652659] PF-04691502 PF-4691502 PHENYLEPHRINE PI-103 PICTILISIB PILARALISIB PILOCARPINE PIRENZEPINE PKI-587 PLINABULIN PP121 PRN694 PROCYCLIDINE PROGESTERONE PROMAZINE PROMETHAZINE PROPANTHELINE PROPIOMAZINE PROTEASOME INHIBITOR PROTEIN KINASE C INHIBITOR PSN-101 PUQUITINIB PWT-33587 PWT33597 PX-866 QUERCETIN R7201 RALOXIFENE RAPAMYCIN RECILISIB RECOMBINANT THROMBOMODULIN RECOMBINANT TISSUE PLASMINOGEN ACTIVATOR RETINOIC ACID RG-7666 RGB-286638 RISPERIDONE ROVELIZUMAB SABCOMELINE SAGOPILONE SARGRAMOSTIM SCOPOLAMINE SELENIUM SF-1126 SF1126 SL422 SOLIFENACIN SONOLISIB SOPHORETIN SR-123781A STAUROSPORINE STRYCHNINE TADOCIZUMAB TAMOXIFEN TASELISIB THEOPHYLLINE THIETHYLPERAZINE THIOCHROME THREO-3-METHYLGLUTAMATE THROMBIN TIROFIBAN TIROFIBAN HYDROCHLORIDE TNF-ALPHA TOLTERODINE TOSEDOSTAT TPI-ASM8 TRAIL TRASTUZUMAB EMTANSINE TRC-105 TRC105 TRIPITRAMINE UH-AH 37 UMECLIDINIUM VALPROIC ACID VARESPLADIB VARESPLADIB METHYL VERUBULIN VINBLASTINE SULFATE VINBURNINE VINCAMINE VINCRISTINE SULFATE VINFLUNINE VINORELBIN DITARTRATE VIRAL MACROPHAGE INFLAMMATORY PROTEIN-II VMCC-I VMIP-I VOSORITIDE VOXTALISIB VS-5584 VU0255035 WIN 51,708 WIN 62,577 WX-037 XANOMELINE XIMELAGATRAN XIMELEGATRAN XL-765 XL147 YM90709 ZK 756326 ZSTK-474
